STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement

Little, Julian; Higgins, Julian P T; Ioannidis, John P A; Moher, David; Gagnon, France; von Elm, Erik; Khoury, Muin J; Cohen, Barbara; Davey-Smith, George; Grimshaw, Jeremy; Scheet, Paul; Gwinn, Marta; Williamson, Robin E; Zou, Guang Yong; Hutchings, Kim; Johnson, Candice Y; Tait, Valerie; Wiens, Miriam; Golding, Jean; van Duijn, Cornelia; ... (2009). STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement. Genetic epidemiology, 33(7), pp. 581-98. Hoboken, N.J.: Wiley-Blackwell 10.1002/gepi.20410

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Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

von Elm, Erik Björn

ISSN:

0741-0395

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:10

Last Modified:

04 May 2014 23:22

Publisher DOI:

10.1002/gepi.20410

PubMed ID:

19278015

Web of Science ID:

000271406100003

URI:

https://boris.unibe.ch/id/eprint/30642 (FactScience: 194895)

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