Regulation of phosphoinositide 3-kinase expression in health and disease

Kok, Klaartje; Geering, Barbara; Vanhaesebroeck, Bart (2009). Regulation of phosphoinositide 3-kinase expression in health and disease. Trends in biochemical sciences, 34(3), pp. 115-27. Cambridge: Elsevier Current Trends 10.1016/j.tibs.2009.01.003

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Both the biology and the therapeutic potential of the phosphoinositide 3-kinase (PI3K) signalling axis have been the subject of intense investigation; however, little is known about the regulation of PI3K expression. Emerging evidence indicates that PI3K levels change in response to cellular stimulation with insulin and nuclear receptor ligands, and during various physiological and pathological processes including differentiation, regeneration, hypertension and cancer. Recently identified mechanisms that control PI3K production include increased gene copy number in cancer, and transcriptional regulation of the p110alpha PI3K gene by FOXO3a, NF-kappaB and p53, and of the PI3K regulatory subunits by STAT3, EBNA-2 and SREBP. In most instances, however, the impact of alterations in PI3K expression on PI3K signalling and disease remains to be established.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Geering Truffer, Barbara

ISSN:

0968-0004

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:10

Last Modified:

04 May 2014 23:22

Publisher DOI:

10.1016/j.tibs.2009.01.003

PubMed ID:

19299143

Web of Science ID:

000265358700007

URI:

https://boris.unibe.ch/id/eprint/30688 (FactScience: 194958)

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