Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells

von Gunten, Stephan; Bochner, Bruce S (2009). Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells. In: Pawankar, Ruby; Holgate, Stephen T; Rosenwasser, Lanny J (eds.) Allergy Frontiers: Classification and Pathomechanisms. Allergy Frontiers: Vol. 2 (pp. 297-313). Japan: Springer 10.1007/978-4-431-88315-9_19

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Siglec-8, the eighth member of the sialic acid-binding, immunoglobulin [Ig]-like lectin family, was initially discovered as a cell surface protein selectively expressed on human eosinophils. It is now know to also be expressed by mast cells and basophils. Siglec-8 engagement with specific antibodies causes apoptosis via caspase and mitochondrial-dependent pathways. For mast cells, inhibition of mediator release, but no apoptosis, is observed. Siglec-F is the closest mouse paralog to Siglec-8, and both selectively bind the sulfated glycan 6’-sulfo-sialyl Lewis X. Antibodies to Siglec-F reduce blood and tissue eosinophil numbers in vivo. This suggests that Siglec-8 may be a useful future therapeutic target for allergic and other eosinophilic disorders.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

von Gunten, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISBN:

978-4-431-88315-9

Series:

Allergy Frontiers

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:10

Last Modified:

18 Mar 2014 00:19

Publisher DOI:

10.1007/978-4-431-88315-9_19

URI:

https://boris.unibe.ch/id/eprint/30702 (FactScience: 194976)

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