A systematic review of the clinical performance of CAD/CAM single-tooth restorations

Wittneben, Julia-Gabriela; Wright, Robert F; Weber, Hans-Peter; Gallucci, German O (2009). A systematic review of the clinical performance of CAD/CAM single-tooth restorations. International journal of prosthodontics, 22(5), pp. 466-71. Lombard, Ill.: Quintessence Publ.

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PURPOSE: This systematic review sought to determine the long-term clinical survival rates of single-tooth restorations fabricated with computer-aided design/computer-assisted manufacture (CAD/CAM) technology, as well as the frequency of failures depending on the CAD/CAM system, the type of restoration, the selected material, and the luting agent. MATERIALS AND METHODS: An electronic search from 1985 to 2007 was performed using two databases: Medline/PubMed and Embase. Selected keywords and well-defined inclusion and exclusion criteria guided the search. All articles were first reviewed by title, then by abstract, and subsequently by a full text reading. Data were assessed and extracted by two independent examiners. The pooled results were statistically analyzed and the overall failure rate was calculated by assuming a Poisson-distributed number of events. In addition, reported failures were analyzed by CAD/CAM system, type of restoration, restorative material, and luting agent. RESULTS: From a total of 1,957 single-tooth restorations with a mean exposure time of 7.9 years and 170 failures, the failure rate was 1.75% per year, estimated per 100 restoration years (95% CI: 1.22% to 2.52%). The estimated total survival rate after 5 years of 91.6% (95% CI: 88.2% to 94.1%) was based on random-effects Poisson regression analysis. CONCLUSIONS: Long-term survival rates for CAD/CAM single-tooth Cerec 1, Cerec 2, and Celay restorations appear to be similar to conventional ones. No clinical studies or randomized clinical trials reporting on other CAD/CAM systems currently used in clinical practice and with follow-up reports of 3 or more years were found at the time of the search.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Division of Fixed Prosthodontics [discontinued]

UniBE Contributor:

Wittneben, Julia




Quintessence Publ.




Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 15:11

Last Modified:

25 Jan 2017 12:16

PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/31053 (FactScience: 195452)

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