A functional model for adult stem cells in epithelial tissues

Verstappen, Jochem; Katsaros, Christos; Torensma, Ruurd; Von den Hoff, Johannes W (2009). A functional model for adult stem cells in epithelial tissues. Wound repair and regeneration, 17(3), pp. 296-305. Hoboken, N.J.: Wiley-Blackwell 10.1111/j.1524-475X.2009.00497.x

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Tissue turnover, regeneration, and repair take place throughout life. Stem cells are key players in these processes. The characteristics and niches of the stem cell populations in different tissues, and even in related tissues, vary extensively. In this review, stem cell differentiation and stem cell contribution to tissue maintenance and regeneration is compared in the epithelia of the skin, the cornea, the lung, and the intestine. A hierarchical model for adult stem cells is proposed, based on the potency of stem cell subpopulations in a specific tissue. The potency is defined in terms of the maintenance, the repair, and the regeneration of the tissue. The niche supplies cues to maintain the specific stem cell potency.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Katsaros, Christos

ISSN:

1067-1927

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 15:11

Last Modified:

25 Jan 2017 12:16

Publisher DOI:

10.1111/j.1524-475X.2009.00497.x

PubMed ID:

19660036

Web of Science ID:

000266244600003

URI:

https://boris.unibe.ch/id/eprint/31059 (FactScience: 195459)

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