When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration

Stricker, Kay H; Takala, Jukka; Hullin, Roger; Ganter, Christoph C (2009). When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration. Anesthesia and analgesia, 109(5), pp. 1640-3. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ANE.0b013e3181b9db63

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Twenty-three hours after heart transplantation, life-threatening acute right heart failure was diagnosed in a patient requiring continuous venovenous hemodiafiltration (CVVHDF). Increasing doses of catecholamines, sedatives, and muscle relaxants administered through a central venous catheter were ineffective. However, a bolus of epinephrine injected through an alternative catheter provoked a hypertensive crisis. Thus, interference with the central venous infusion by the dialysis catheter was suspected. The catheters were changed, and hemodynamics stabilized at lower catecholamine doses. When the effects of IV drugs are inadequate in patients receiving CVVHDF, interference with adjacent catheters resulting in elimination of the drug by CVVHDF should be suspected.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Stricker, Kay; Takala, Jukka and Ganter, Christoph




Lippincott Williams & Wilkins




Factscience Import

Date Deposited:

04 Oct 2013 15:11

Last Modified:

04 May 2014 23:22

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https://boris.unibe.ch/id/eprint/31285 (FactScience: 195732)

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