Patterns of recurrence of early breast cancer according to estrogen receptor status: a therapeutic target for a quarter of a century

Pagani, Olivia; Price, Karen N; Gelber, Richard D; Castiglione-Gertsch, Monica; Holmberg, Stig B; Lindtner, Jurij; Thürlimann, Beat; Collins, John; Fey, Martin F; Coates, Alan S; Goldhirsch, Aron (2009). Patterns of recurrence of early breast cancer according to estrogen receptor status: a therapeutic target for a quarter of a century. Breast cancer research and treatment, 117(2), pp. 319-24. Dordrecht: Springer 10.1007/s10549-008-0282-0

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The current therapeutic strategy in breast cancer is to identify a target, such as estrogen receptor (ER) status, for tailoring treatments. We investigated the patterns of recurrence with respect to ER status for patients treated in two randomized trials with 25 years' median follow-up. In the ER-negative subpopulations most breast cancer events occurred within the first 5-7 years after randomization, while in the ER-positive subpopulations breast cancer events were spread through 10 years. In the ER-positive subpopulation, 1 year endocrine treatment alone significantly prolonged disease-free survival (DFS) with no additional benefit observed by adding 1 year of chemotherapy. In the small ER-negative subpopulation chemo-endocrine therapy had a significantly better DFS than endocrine alone or no treatment. Despite small numbers of patients, "old-fashioned" treatments, and competing causes of treatment failure, the value of ER status as a target for response to adjuvant treatment is evident through prolonged follow-up.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Fey, Martin

ISSN:

0167-6806

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:11

Last Modified:

07 Jul 2022 14:56

Publisher DOI:

10.1007/s10549-008-0282-0

PubMed ID:

19137426

Web of Science ID:

000269005500011

BORIS DOI:

10.48350/31376

URI:

https://boris.unibe.ch/id/eprint/31376 (FactScience: 195870)

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