Immune response deviation and enhanced expression of chemokine receptor CCR4 in TBI patients due to unknown serum factors

Cadosch, Dieter; Al-Mushaiqri, Mohamed S; Gautschi, Oliver P; Chan, Erwin; Jung, Florian J; Skirving, Allan P; Filgueira, Luis (2009). Immune response deviation and enhanced expression of chemokine receptor CCR4 in TBI patients due to unknown serum factors. Injury - international journal of the care of the injured, 41(6), e4-9. Oxford: Elsevier 10.1016/j.injury.2009.09.001

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BACKGROUND: Severe brain trauma leads to an activation of the immune system. To this date, neither the exact perturbation of the specific immune reaction induced by the traumatic brain injury (TBI), nor the interactions leading to the infiltration of peripheral immune cells into the brain are fully understood. PATIENTS AND METHODS: Serum was collected from 17 patients with TBI and a long bone fracture, 24 patients with an isolated long bone fracture and from healthy individuals. The effect of the serum on normal human monocytes and T-lymphocytes was tested in vitro by assessing proliferation and expression of surface markers, chemokine receptors and cytokines. RESULTS: Serum collected from patients with a TBI and a long bone fracture increased the expression of the chemokine receptor CCR4 in monocytes when compared to patients with an isolated long bone fracture. Extending this comparison to T-lymphocytes, the serum from TBI patients induced lower proliferation rates and decreased expression of the pro-inflammatory cytokine TNF-alpha, while simultaneously increasing the secretion of immune-modulatory cytokines (IL-4, IL-10 and TGF-beta) (p<0.05). CONCLUSION: Patients with a TBI release currently unknown soluble factors into the circulating blood that up regulate expression of chemokine receptor CCR4 in peripheral blood monocytes whilst concurrently inducing expression of immunosuppressive cytokines by activated T-lymphocytes.

Item Type:	Journal Article (Original Article)
ISSN:	0020-1383
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:11
Last Modified:	08 Jun 2016 10:52
Publisher DOI:	10.1016/j.injury.2009.09.001
PubMed ID:	19781699
Web of Science ID:	000277700000025
URI:	https://boris.unibe.ch/id/eprint/31377 (FactScience: 195871)