Pabst, T; Eyholzer, M; Fos, J; Mueller, B U (2009). Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis. British journal of cancer, 100(8), pp. 1343-6. Basingstoke: Nature Publishing Group 10.1038/sj.bjc.6604977
Full text not available from this repository. (Request a copy)CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. The majority of AML patients have both types of mutations. We assessed the prognostic significance of single (n=7) and double (n=12) CEBPA mutations among 224 AML patients. Double CEBPA mutations conferred a decisively favourable overall (P=0.006) and disease-free survival (P=0.013). However, clinical outcome of patients with single CEBPA mutations was not different from CEBPA wild-type patients. In a multivariable analysis, only double -- but not single -- CEBPA mutations were identified as independent prognostic factors. These findings indicate heterogeneity within AML patients with CEBPA mutations.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine |
UniBE Contributor: |
Pabst, Thomas Niklaus, Müller, Beatrice Ursula |
ISSN: |
0007-0920 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:11 |
Last Modified: |
02 Mar 2023 23:23 |
Publisher DOI: |
10.1038/sj.bjc.6604977 |
PubMed ID: |
19277035 |
Web of Science ID: |
000265575000018 |
URI: |
https://boris.unibe.ch/id/eprint/31386 (FactScience: 195883) |
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