Rothschild, Sacha; Dolder, Mathias; Seifert, Burkhardt; Lütolf, Urs M; Ciernik, I Frank (2009). Radiation therapy for HIV-associated diffuse large cell non-Hodgkin lymphoma. Journal of the International Association of Physicians in AIDS Care JIAPAC, 8(4), pp. 239-48. Chicago, Ill.: International Association of Physicians in AIDS Care
Full text not available from this repository. (Request a copy)PURPOSE: To report the clinical experience with external beam radiotherapy (RT) for AIDS-related lymphoma (ARL) with or without the involvement of the central nervous system (CNS) in HIV-infected patients. PATIENTS AND METHODS: Clinical outcome of 24 HIV-seropositive patients with ARL treated with RT from 1995 to 2004 was reviewed, testing factors associated with outcome. RESULTS: After 1 and 5 years, the overall survival was 65% and 35%, respectively. The mean RT dose was 31 Gy after normalization to fractions of daily 2 Gy (range, 7.8-47.2 Gy). Radiotherapy dose was associated with survival in univariate (P = .04) and multivariate analysis (P = .01). Other factors in univariate analysis associated with outcome were viral load (VL), highly active antiretroviral therapy (HAART), ARL stage, and CNS involvement. Patients with CNS involvement achieved complete response in 46% and improved clinical performance was seen in 73%. CONCLUSIONS: After chemotherapy, RT in combination with HAART is highly active, and RT should be encouraged especially after suboptimal responses to induction treatment.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Rothschild, Sacha |
ISSN: |
1545-1097 |
Publisher: |
International Association of Physicians in AIDS Care |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:11 |
Last Modified: |
05 Dec 2022 14:21 |
PubMed ID: |
19589920 |
URI: |
https://boris.unibe.ch/id/eprint/31388 (FactScience: 195886) |
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