Dose-response effect of interleukin (IL)-1beta, tumour necrosis factor (TNF)-alpha, and interferon-y on the in vitro production of epithelial neutrophil activating peptide-78 (ENA-78), IL-8, and IL-6 by human endometrial stromal cells

Bersinger, Nick A; Günthert, Andreas R; McKinnon, Brett; Johann, Silke; Mueller, Michael D (2011). Dose-response effect of interleukin (IL)-1beta, tumour necrosis factor (TNF)-alpha, and interferon-y on the in vitro production of epithelial neutrophil activating peptide-78 (ENA-78), IL-8, and IL-6 by human endometrial stromal cells. Archives of gynecology and obstetrics, 283(6), pp. 1291-6. Berlin: Springer-Verlag 10.1007/s00404-010-1520-3

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The production of epithelial neutrophil activating peptide-78 (NA-78) and the interleukins IL-8 and IL-6 by endometrial stromal cells is stimulated by pro-inflammatory interleukin-1 (IL-1) and tumour necrosis factor-α (TNF-α). IL-8 is suggested to play a role in the pathogenesis of endometriosis, and in these women the peritoneal fluid concentrations of ENA-78 and IL-8 are increased. TNF-α has been tested together with interferon-γ because of their cooperative stimulation of IL-6. The release of IL-8, however, is inhibited with increasing interferon levels. The aim of the study was the analysis of the production of ENA-78, IL-6 and IL-8 by cultured human endometrial stromal cells in the presence of varying concentrations of IL-1β, TNF-α, and interferon-γ.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Bersinger, Nick A.; Günthert, Andreas Reinhold; Mc Kinnon, Brett and Mueller, Michael

ISSN:

0932-0067

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:13

Last Modified:

26 Jun 2018 13:18

Publisher DOI:

10.1007/s00404-010-1520-3

PubMed ID:

20505949

Web of Science ID:

000290536100017

BORIS DOI:

10.7892/boris.3139

URI:

https://boris.unibe.ch/id/eprint/3139 (FactScience: 206610)

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