Visibility of vascular phenylalanine in dynamic uptake studies in humans using magnetic resonance spectroscopy

Kreis, Roland; Salvisberg, Christian; Lutz, Thomas; Boesch, Chris; Pietz, Joachim (2005). Visibility of vascular phenylalanine in dynamic uptake studies in humans using magnetic resonance spectroscopy. Magnetic resonance in medicine, 54(2), pp. 435-8. New York, N.Y.: Wiley-Liss 10.1002/mrm.20539

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In general, vascular contributions to the in vivo magnetic resonance (MR) brain spectrum are too small to be relevant. In cerebral uptake studies, however, vascular contributions may constitute a major confounder. MR visibility of vascular Phe was investigated by recording localized spectra from fully oxygenated and well-mixed whole blood. Blood Phe levels determined by MR spectroscopy (MRS) and ion-exchange chromatography showed excellent correlation. In addition, effects of blood flow were shown to have a small effect on signal amplitude with the MRS methodology used. Hence, blood Phe is almost completely MR visible at 1.5 T, even though it is severely broadened at higher fields. Without appropriate correction, cerebral Phe influx in studies of brain Phe uptake in phenylketonuria patients or healthy subjects would appear to be faster and lead to higher levels. Similar effects are envisaged for studies of ethanol or glucose uptake across the blood-brain barrier.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

UniBE Contributor:

Kreis, Roland and Bösch, Christoph Hans

ISSN:

0740-3194

Publisher:

Wiley-Liss

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:11

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1002/mrm.20539

PubMed ID:

16032663

Web of Science ID:

000230765700022

URI:

https://boris.unibe.ch/id/eprint/31496 (FactScience: 196082)

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