Gray matter volume differences specific to formal thought disorder in schizophrenia

Horn, Helge; Federspiel, Andrea; Wirth, Miranka; Müller, Thomas J; Wiest, Roland; Walther, Sebastian; Strik, Werner (2010). Gray matter volume differences specific to formal thought disorder in schizophrenia. Psychiatry research, 182(2), pp. 183-6. Amsterdam: Elsevier 10.1016/j.pscychresns.2010.01.016

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Formal thought disorder (FTD) is one of the main symptoms of schizophrenia. To date there are no whole brain volumetric studies investigating gray matter (GM) differences specifically associated with FTD. Here, we studied 20 right-handed schizophrenia patients that differed in the severity of formal thought disorder and 20 matched healthy controls, using voxel-based morphometry (VBM). The severity of FTD was measured with the Scale for the Assessment of Thought, Language, and Communication. The severity was negatively correlated with the GM volume of the left superior temporal sulcus, the left temporal pole, the right middle orbital gyrus and the right cuneus/lingual gyrus. Structural abnormalities specific for FTD were found to be unrelated to GM differences associated with schizophrenia in general. The specific GM abnormalities within the left temporal lobe may help to explain language disturbances included in FTD.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued] 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
UniBE Contributor:	Horn, Helge Joachim, Federspiel, Andrea, Wirth, Miranka, Müller, Thomas (A), Wiest, Roland Gerhard Rudi, Walther, Sebastian, Strik, Werner
ISSN:	0165-1781
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:08
Last Modified:	29 Mar 2023 23:31
Publisher DOI:	10.1016/j.pscychresns.2010.01.016
PubMed ID:	20418073
Web of Science ID:	000278701500016
URI:	https://boris.unibe.ch/id/eprint/315 (FactScience: 197502)