Gray matter volume differences specific to formal thought disorder in schizophrenia

Horn, Helge; Federspiel, Andrea; Wirth, Miranka; Müller, Thomas J; Wiest, Roland; Walther, Sebastian; Strik, Werner (2010). Gray matter volume differences specific to formal thought disorder in schizophrenia. Psychiatry research, 182(2), pp. 183-6. Amsterdam: Elsevier 10.1016/j.pscychresns.2010.01.016

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Formal thought disorder (FTD) is one of the main symptoms of schizophrenia. To date there are no whole brain volumetric studies investigating gray matter (GM) differences specifically associated with FTD. Here, we studied 20 right-handed schizophrenia patients that differed in the severity of formal thought disorder and 20 matched healthy controls, using voxel-based morphometry (VBM). The severity of FTD was measured with the Scale for the Assessment of Thought, Language, and Communication. The severity was negatively correlated with the GM volume of the left superior temporal sulcus, the left temporal pole, the right middle orbital gyrus and the right cuneus/lingual gyrus. Structural abnormalities specific for FTD were found to be unrelated to GM differences associated with schizophrenia in general. The specific GM abnormalities within the left temporal lobe may help to explain language disturbances included in FTD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Horn, Helge Joachim; Federspiel, Andrea; Wirth, Miranka; Müller, Thomas Jörg; Wiest, Roland; Walther, Sebastian and Strik, Werner

ISSN:

0165-1781

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

06 Dec 2013 13:19

Publisher DOI:

10.1016/j.pscychresns.2010.01.016

PubMed ID:

20418073

Web of Science ID:

000278701500016

URI:

https://boris.unibe.ch/id/eprint/315 (FactScience: 197502)

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