Distribution of intramyocellular lipids in human calf muscles as determined by MR spectroscopic imaging

Vermathen, Peter; Kreis, Roland; Boesch, Chris (2004). Distribution of intramyocellular lipids in human calf muscles as determined by MR spectroscopic imaging. Magnetic resonance in medicine, 51(2), pp. 253-62. New York, N.Y.: Wiley-Liss 10.1002/mrm.10721

Full text not available from this repository. (Request a copy)

In this study the distribution of intramyocellular lipids (IMCL) in human calf muscles was determined by 1H-MR spectroscopic imaging (MRSI) measurements. An obstacle for MRSI measurements in the calf, including different muscles, is the inevitable inclusion of regions with high concentrations of extramyocellular lipids (EMCL). This can lead to signal bleeding and consequently to unpredictable overlaps of IMCL resonances with EMCL in voxels of interest. The results of this study show that signal bleeding from EMCL can be substantially reduced in voxels from calf muscles by the application of a lipid extrapolation (LE) procedure (Haupt et al., Magn Reson Med 1996;35:678). The spectra of all voxels located within muscle tissue were fitted, and the metabolite values were assigned to one of 10 different muscles based on image segmentation. Significant IMCL differences between some muscles were obtained, with high values in m. soleus and two to three times lower values in the tibialis anterior, tibialis posterior, and gastrocnemius muscles. In addition to gross differences between muscles, significant intersubject differences were observed in both IMCL content and distribution over different muscles. A significant correlation between fiber orientation (obtained from orientation-dependent dipolar coupling of creatine and taurine resonances) and IMCL content was found, indicating that IMCL content is directly correlated to biomechanical properties.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

UniBE Contributor:

Vermathen, Peter; Kreis, Roland and Bösch, Christoph Hans






Factscience Import

Date Deposited:

04 Oct 2013 15:12

Last Modified:

16 Apr 2014 15:29

Publisher DOI:


PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/31500 (FactScience: 196086)

Actions (login required)

Edit item Edit item
Provide Feedback