Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption

Lazzarato, Loretta; Rolando, Barbara; Lolli, Marco L; Tron, Gian Cesare; Fruttero, Roberta; Gasco, Alberto; Deleide, Guido; Guenther, Harald L (2005). Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption. Journal of medicinal chemistry, 48(5), pp. 1322-9. Easton, Pa.: American Chemical Society 10.1021/jm040830d

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A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of (99m)Tc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of pre-osteoclasts to functional osteoclasts induced by receptor activator of NF-kappaB ligand (RANKL), through a prevalent NO-dependent mechanism.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung
UniBE Contributor:	Günther, Harald Ludwig
ISSN:	0022-2623
Publisher:	American Chemical Society
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:12
Last Modified:	05 Dec 2022 14:22
Publisher DOI:	10.1021/jm040830d
PubMed ID:	15743175
Web of Science ID:	000227392200004
URI:	https://boris.unibe.ch/id/eprint/31654 (FactScience: 196301)