Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption

Lazzarato, Loretta; Rolando, Barbara; Lolli, Marco L; Tron, Gian Cesare; Fruttero, Roberta; Gasco, Alberto; Deleide, Guido; Guenther, Harald L (2005). Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption. Journal of medicinal chemistry, 48(5), pp. 1322-9. Easton, Pa.: American Chemical Society 10.1021/jm040830d

Full text not available from this repository. (Request a copy)

A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of (99m)Tc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of pre-osteoclasts to functional osteoclasts induced by receptor activator of NF-kappaB ligand (RANKL), through a prevalent NO-dependent mechanism.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung

UniBE Contributor:

Günther, Harald Ludwig

ISSN:

0022-2623

Publisher:

American Chemical Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:12

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1021/jm040830d

PubMed ID:

15743175

Web of Science ID:

000227392200004

URI:

https://boris.unibe.ch/id/eprint/31654 (FactScience: 196301)

Actions (login required)

Edit item Edit item
Provide Feedback