Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin

Baltzer, A; Svanborg, C; Jaggi, R (2004). Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin. Cellular and molecular life sciences, 61(10), pp. 1221-8. Basel: Birkhäuser-Verlag 10.1007/s00018-004-4046-7

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Apoptosis is essential to eliminate secretory epithelial cells during the involution of the mammary gland. The environmental regulation of this process is however, poorly understood. This study tested the effect of HAMLET (human alpha-lactalbumin made lethal to tumor cells) on mammary cells. Plastic pellets containing HAMLET were implanted into the fourth inguinal mammary gland of lactating mice for 3 days. Exposure of mammary tissue to HAMLET resulted in morphological changes typical for apoptosis and in a stimulation of caspase-3 activity in alveolar epithelial cells near the HAMLET pellets but not more distant to the pellet or in contralateral glands. The effect was specific for HAMLET and no effects were observed when mammary glands were exposed to native a-lactalbumin or fatty acid alone. HAMLET also induced cell death in vitro in a mouse mammary epithelial cell line. The results suggest that HAMLET can mediate apoptotic cell death in mammary gland tissue.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pathologie > Forschungsgruppe Molekularbiologie

UniBE Contributor:

Baltzer, Anna and Jaggi, Rolf

ISSN:

1420-682X

Publisher:

Birkhäuser-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:12

Last Modified:

30 Oct 2019 18:13

Publisher DOI:

10.1007/s00018-004-4046-7

PubMed ID:

15141307

Web of Science ID:

000221370600009

BORIS DOI:

10.7892/boris.31658

URI:

https://boris.unibe.ch/id/eprint/31658 (FactScience: 196305)

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