Xenograft rejection: IgG1, complement and NK cells team up to activate and destroy the endothelium

Rieben, Robert; Seebach, Jörg D (2005). Xenograft rejection: IgG1, complement and NK cells team up to activate and destroy the endothelium. Trends in immunology, 26(1), pp. 2-5. Oxford: Elsevier Current Trends 10.1016/j.it.2004.11.011

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Acute vascular rejection represents a formidable barrier to clinical xenotransplantation and it is known that this type of rejection can also be initiated by xenoreactive antibodies that have limited complement-activating ability. Using a sophisticated mouse model, a recent study has provided in vivo evidence for the existence of an IgG(1)-mediated vascular rejection, which uniquely depends on both the activation of complement and interactions with FcgammaRIII on natural killer (NK) cells.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe

UniBE Contributor:

Rieben, Robert

ISSN:

1471-4906

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:12

Last Modified:

06 Dec 2013 13:58

Publisher DOI:

10.1016/j.it.2004.11.011

PubMed ID:

15629401

Web of Science ID:

000226566000001

URI:

https://boris.unibe.ch/id/eprint/31677 (FactScience: 196326)

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