Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes

Bengtsson, Therese; Aszodi, Attila; Nicolae, Claudia; Hunziker, Ernst B; Lundgren-Akerlund, Evy; Fässler, Reinhard (2005). Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. Journal of cell science, 118(Pt 5), pp. 929-36. Cambridge: Company of Biologists Limited 10.1242/jcs.01678

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Integrin alpha10beta1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha10 integrin during development, we generated mice carrying a constitutive deletion of the alpha10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures in control mice. These results demonstrate that integrin alpha10beta1 plays a specific role in growth plate morphogenesis and function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Orthopädische Chirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Orthopädische Chirurgie

UniBE Contributor:

Hunziker, Ernst Bruno

ISSN:

0021-9533

Publisher:

Company of Biologists Limited

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:12

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1242/jcs.01678

PubMed ID:

15713743

Web of Science ID:

000228378400009

URI:

https://boris.unibe.ch/id/eprint/31686 (FactScience: 196345)

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