GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton

Gregory, Patrick; Kraemer, Elisabeth; Zürcher, Gisela; Gentinetta, René; Rohrbach, Valeria; Brodbeck, Urs; Andres, Anne-Catherine; Ziemiecki, Andrew; Bütikofer, Peter (2005). GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton. Bone, 37(2), pp. 139-47. New York, N.Y.: Elsevier 10.1016/j.bone.2005.04.015

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Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in serum and has a well-characterized biochemistry; however, its physiological role is completely unknown. Previous investigations into GPI-PLD have focused on the adult animal or on in vitro systems and a putative role in development has been neither proposed nor investigated. We describe the first evidence of GPI-PLD expression during mouse embryonic ossification. GPI-PLD expression was detected predominantly at sites of skeletal development, increasing during the course of gestation. GPI-PLD was observed during both intramembraneous and endochondral ossification and localized predominantly to the extracellular matrix of chondrocytes and to primary trabeculae of the skeleton. In addition, the mouse chondrocyte cell line ATDC5 expressed GPI-PLD after experimental induction of differentiation. These results implicate GPI-PLD in the process of bone formation during mouse embryogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Tiefenau Hospital (discontinued) > Forschungsgruppe Biologie und Karzinogenese der Brustdrüse (discontinued)

UniBE Contributor:

Zürcher, Gisela; Rohrbach, Valeria; Andres, Anne Catherine and Ziemiecki, Andrew

ISSN:

8756-3282

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:12

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1016/j.bone.2005.04.015

PubMed ID:

15946906

Web of Science ID:

000230948800001

URI:

https://boris.unibe.ch/id/eprint/31739 (FactScience: 196406)

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