Schlapbach, L J; Aebi, C; Hansen, A G; Hirt, A; Jensenius, J C; Ammann, R A (2009). H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients. Clinical and experimental immunology, 157(1), pp. 83-9. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2249.2009.03957.x
Full text not available from this repository.H-ficolin (Hakata antigen, ficolin-3) activates the lectin pathway of complement similar to mannose-binding lectin. However, its impact on susceptibility to infection is currently unknown. This study investigated whether the serum concentration of H-ficolin at diagnosis is associated with fever and neutropenia (FN) in paediatric cancer patients. H-ficolin was measured by time-resolved immunofluorometric assay in serum taken at cancer diagnosis from 94 children treated with chemotherapy. The association of FN episodes with H-ficolin serum concentration was analysed by multivariate Poisson regression. Median concentration of H-ficolin in serum was 26 mg/l (range 6-83). Seven (7%) children had low H-ficolin (< 14 mg/l). During a cumulative chemotherapy exposure time of 82 years, 177 FN episodes were recorded, 35 (20%) of them with bacteraemia. Children with low H-ficolin had a significantly increased risk to develop FN [relative risk (RR) 2.24; 95% confidence interval (CI) 1.38-3.65; P = 0.004], resulting in prolonged duration of hospitalization and of intravenous anti-microbial therapy. Bacteraemia occurred more frequently in children with low H-ficolin (RR 2.82; CI 1.02-7.76; P = 0.045). In conclusion, low concentration of H-ficolin was associated with an increased risk of FN, particularly FN with bacteraemia, in children treated with chemotherapy for cancer. Low H-ficolin thus represents a novel risk factor for chemotherapy-related infections.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Schlapbach, Luregn Jan, Aebi, Christoph, Hirt, Andreas, Ammann, Roland |
ISSN: |
0009-9104 |
Publisher: |
Blackwell Scientific Publications |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 15:12 |
Last Modified: |
05 Dec 2022 14:22 |
Publisher DOI: |
10.1111/j.1365-2249.2009.03957.x |
PubMed ID: |
19659773 |
Web of Science ID: |
000266813500010 |
URI: |
https://boris.unibe.ch/id/eprint/31794 (FactScience: 196475) |
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