von der Weid, N; Wagner, B; Angst, R; Arnet, B; Baumgartner, C; Beck, D; Bleher, A; Caflisch, U; Delaleu, B; Feldges, A (1994). Treatment of relapsing acute lymphoblastic leukemia in childhood. III. Experiences with 54 first bone marrow, nine isolated testicular, and eight isolated central nervous system relapses observed 1985-1989. Medical and pediatric oncology, 22(6), pp. 361-9. New York, N.Y.: Wiley-Liss
Full text not available from this repository. (Request a copy)Of 54 children with acute lymphoblastic leukemia (ALL) and first hematological recurrence observed between 1985 and 1989, 31 relapsed while still on treatment and 23 after cessation of therapy. Of the former, only one survived. Of the latter, 11 children survived after a minimum follow-up of 25 months. During the same period, a first isolated testicular relapse was observed in nine boys, of whom six survived, and an isolated CNS relapse in eight patients, of whom three survived. As a rule, survivors of a bone marrow or testicular relapse were doing well while those surviving a CNS relapse had considerable neuropsychological sequelae. These results, compared with those of two preceding studies, suggest that with intensification of front-line treatments, it becomes more difficult to rescue children who relapse, particularly those with a bone marrow relapse while on therapy.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Wagner, Bendicht Peter |
ISSN: |
0098-1532 |
Publisher: |
Wiley-Liss |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 15:12 |
Last Modified: |
05 Dec 2022 14:22 |
PubMed ID: |
8152396 |
Web of Science ID: |
A1994NG22700001 |
URI: |
https://boris.unibe.ch/id/eprint/31890 (FactScience: 196663) |
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