Expression of defensins in non-infected araneomorph spiders

Baumann, Tommy; Kuhn-Nentwig, Lucia; Largiadèr, Carlo R; Nentwig, Wolfgang (2010). Expression of defensins in non-infected araneomorph spiders. Cellular and molecular life sciences, 67(15), pp. 2643-51. Basel: SP Birkhäuser Verlag Basel 10.1007/s00018-010-0354-2

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Defensins are a major family of antimicrobial peptides found throughout the phylogenetic tree. From the spider species: Cupiennius salei, Phoneutria reidyi, Polybetes pythagoricus, Tegenaria atrica, and Meta menardi, defensins belonging to the 'ancestral' class of invertebrate defensins were cloned and sequenced. The deduced amino acid sequences contain the characteristic six cysteines of this class of defensins and reveal precursors of 60 or 61 amino acid residues. The mature peptides consist of 37 amino acid residues, showing up to 70% identities with tick and scorpion defensins. In C. salei, defensin mRNA was found to be constitutively expressed in hemocytes, ovaries, subesophageal nerve mass, hepatopancreas, and muscle tissue. This is the first report presenting and comparing antimicrobial peptides belonging to the family of defensins from spiders.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Community Ecology
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Baumann, Tommy; Kuhn-Nentwig, Lucia; Largiadèr, Carlo Rodolfo and Nentwig, Wolfgang

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
500 Science > 580 Plants (Botany)

ISSN:

1420-682X

Publisher:

SP Birkhäuser Verlag Basel

Language:

English

Submitter:

Tommy Baumann

Date Deposited:

04 Oct 2013 14:13

Last Modified:

26 Jun 2018 14:02

Publisher DOI:

10.1007/s00018-010-0354-2

PubMed ID:

20358249

Web of Science ID:

000279127900009

BORIS DOI:

10.7892/boris.3195

URI:

https://boris.unibe.ch/id/eprint/3195 (FactScience: 206811)

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