Repigmentation by outer-root-sheath-derived melanocytes: proof of concept in vitiligo and leucoderma

Vanscheidt, Wolfgang; Hunziker, Thomas (2009). Repigmentation by outer-root-sheath-derived melanocytes: proof of concept in vitiligo and leucoderma. Dermatology, 218(4), pp. 342-3. Basel: Karger 10.1159/000197467

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BACKGROUND: Treatment of depigmented skin is an unmet medical need. OBJECTIVE: Melanocytes or stem cells thereof residing in the outer root sheath (ORS) of hair follicles might be used to repigment skin. METHODS: After de-epidermisation, autologous ORS cell solutions were applied to 5 patients with vitiligo and 1 with leucoderma. RESULTS: Stable repigmentation in a variable percentage was documented in all the patients. CONCLUSION: Applying ORS-derived melanocytes is a promising technology to improve autologous melanocyte transplantation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Hunziker, Thomas

ISSN:

1018-8665

Publisher:

Karger

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1159/000197467

PubMed ID:

19174603

Web of Science ID:

000265799000009

URI:

https://boris.unibe.ch/id/eprint/32042 (FactScience: 196885)

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