Octreotide treatment of patients with hepatocellular carcinoma--a retrospective single centre controlled study

Schöniger-Hekele, Maximilian; Kettenbach, Joachim; Peck-Radosavljevic, Markus; Müller, Christian (2009). Octreotide treatment of patients with hepatocellular carcinoma--a retrospective single centre controlled study. Journal of experimental & clinical cancer research, 28, p. 142. Roma: APSIT 10.1186/1756-9966-28-142

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BACKGROUND: Studies of treatment with octreotide of patients with hepatocellular carcinoma (HCC) gave conflicting results. We analyzed retrospectively the survival of our patients treated with octreotide monotherapy and compared it to stage-matched patients who received either TACE, multimodal therapy or palliative care. METHODS: 95 patients seen at the department of Gastroenterology and Hepatology, Medical University of Vienna with HCC in BCLC stage A or B, who received either TACE, multimodal therapy, long-acting octreotide or palliative care were reviewed for this retrospective study. RESULTS: Survival rates of patients with BCLC stage B and any "active" treatment (long-acting octreotide, TACE or multimodal therapy) were significantly higher (22.4, 22.0, 35.5 months) compared to patients who received palliative care only (2.9 months). Survival rates of patients with BCLC stage A and "active" treatment (31.4, 37.3, 40.2 months) compared to patients who received only palliative care (15.1 months) did not show statistically significant differences. Octreotide monotherapy showed a similar outcome compared to patients who received TACE or multimodal therapy. CONCLUSION: Survival under octreotide treatment was not different compared to TACE or multimodal therapy and might be a therapeutic option for patients with HCC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Kettenbach, Joachim

ISSN:

0392-9078

Publisher:

APSIT

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1186/1756-9966-28-142

PubMed ID:

19887008

Web of Science ID:

000272250600002

URI:

https://boris.unibe.ch/id/eprint/32045 (FactScience: 196890)

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