Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany

Marczynski, Boleslaw; Pesch, Beate; Wilhelm, Michael; Rossbach, Bernd; Preuss, Ralf; Hahn, Jens-Uwe; Rabstein, Sylvia; Raulf-Heimsoth, Monika; Seidel, Albrecht; Rihs, Hans-Peter; Adams, Ansgar; Scherenberg, Michael; Erkes, Anja; Engelhardt, Beate; Straif, Kurt; Käfferlein, Heiko Udo; Angerer, Jürgen; Brüning, Thomas (2009). Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany. Archives of toxicology, 83(10), pp. 947-57. Berlin: Springer 10.1007/s00204-009-0444-9

Full text not available from this repository. (Request a copy)

Exposure to polycyclic aromatic hydrocarbons (PAH) and DNA damage were analyzed in coke oven (n = 37), refractory (n = 96), graphite electrode (n = 26), and converter workers (n = 12), whereas construction workers (n = 48) served as referents. PAH exposure was assessed by personal air sampling during shift and biological monitoring in urine post shift (1-hydroxypyrene, 1-OHP and 1-, 2 + 9-, 3-, 4-hydroxyphenanthrenes, SigmaOHPHE). DNA damage was measured by 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and DNA strand breaks in blood post shift. Median 1-OHP and SigmaOHPHE were highest in converter workers (13.5 and 37.2 microg/g crea). The industrial setting contributed to the metabolite concentrations rather than the air-borne concentration alone. Other routes of uptake, probably dermal, influenced associations between air-borne concentrations and levels of PAH metabolites in urine making biomonitoring results preferred parameters to assess exposure to PAH. DNA damage in terms of 8-oxo-dGuo and DNA strand breaks was higher in exposed workers compared to referents ranking highest for graphite-electrode production. The type of industry contributed to genotoxic DNA damage and DNA damage was not unequivocally associated to PAH on the individual level most likely due to potential contributions of co-exposures.

Item Type:

Journal Article (Original Article)

ISSN:

0340-5761

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1007/s00204-009-0444-9

PubMed ID:

19543712

Web of Science ID:

000269911200008

URI:

https://boris.unibe.ch/id/eprint/32139 (FactScience: 197066)

Actions (login required)

Edit item Edit item
Provide Feedback