Neurohormonal regulation of cardiac ion channels in chronic heart failure

Kurokawa, Junko; Abriel, Hugues (2009). Neurohormonal regulation of cardiac ion channels in chronic heart failure. Journal of cardiovascular pharmacology, 54(2), pp. 98-105. Hagerstown, Md.: Wolters Kluwer Lippincott Williams & Wilkins 10.1097/FJC.0b013e3181b2b6d4

Full text not available from this repository. (Request a copy)

Alteration of neurohormonal homeostasis is a hallmark of the pathophysiology of chronic heart failure (CHF). In particular, overactivation of the renin-angiotensin-aldosterone system and the sympathetic catecholaminergic system is consistently observed. Chronic overactivation of these hormonal pathways leads to a detrimental arrhythmogenic remodeling of cardiac tissue due to dysregulation of cardiac ion channels. Sudden cardiac death resulting from ventricular arrhythmias is a major cause of mortality in patients with CHF. All the drug classes known to reduce mortality in patients with CHF are neurohormonal blockers. The aim of this review was to provide an overview of how cardiac ion channels are regulated by hormones known to play a central role in the pathogenesis of CHF.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten

UniBE Contributor:

Abriel, Hugues

ISSN:

0160-2446

Publisher:

Wolters Kluwer Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

06 Dec 2013 13:59

Publisher DOI:

10.1097/FJC.0b013e3181b2b6d4

PubMed ID:

19597366

Web of Science ID:

000269469300002

URI:

https://boris.unibe.ch/id/eprint/32216 (FactScience: 197222)

Actions (login required)

Edit item Edit item
Provide Feedback