Assessment of splanchnic blood flow using magnetic resonance imaging

Barthelmes, Daniel; Parviainen, Ilkka; Vainio, Pauli; Vanninen, Ritva; Takala, Jukka; Ikonen, Aki; Tueller, David; Jakob, Stephan M (2009). Assessment of splanchnic blood flow using magnetic resonance imaging. European journal of gastroenterology & hepatology, 21(6), pp. 693-700. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MEG.0b013e32831a86e0

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BACKGROUND AND AIMS: The splanchnic circulation has an important function in the body under both physiological and pathophysiological conditions. Despite its importance, no reliable noninvasive procedures for estimating splanchnic circulation have been established. The aim of this study was to evaluate MRI as a tool for assessing intra-abdominal blood flows of the aorta, portal vein (VPO) and the major intestinal and hepatic vessels. METHODS: In nine healthy volunteers, the proximal aorta (AOP) and distal abdominal aorta (AOD), superior mesenteric artery (SAM), celiac trunk (CTR), hepatic arteries (common and proper hepatic arteries, AHC and AHP, respectively), and VPO were localized on contrast-enhanced magnetic resonance angiography images. Volumetric flow was measured using a two-dimensional cine echocardiogram-gated phase contrast technique. Measurements were taken before and 30 min after continuous intravenous infusion of somatostatin (250 microg/h) and were independently evaluated by two investigators. RESULTS: Blood flow measured by MRI in the VPO, SAM, AOP, AHP, and CTR significantly decreased after drug infusion. Flows in the AOD and AHC showed a tendency to decrease (P>0.05). Interrater agreement on flows in MRI was very good for large vessels (VPO, AOP, and AOD), with a concordance correlation coefficient of 0.94, as well as for smaller vessels such as the CTR, AHC, AHP, and SAM (concordance correlation coefficient =0.78). CONCLUSION: Somatostatin-induced blood flow changes in the splanchnic region were reliably detected by MRI. MRI may be useful for the noninvasive assessment of blood flow changes in the splanchnic region.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Barthelmes, Daniel; Takala, Jukka and Jakob, Stephan

ISSN:

0954-691X

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

06 Dec 2013 13:59

Publisher DOI:

10.1097/MEG.0b013e32831a86e0

PubMed ID:

19293721

Web of Science ID:

000266138100015

URI:

https://boris.unibe.ch/id/eprint/32218 (FactScience: 197227)

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