Age-dependent suppression of SERCA2a mRNA in pediatric atrial myocardium

Pavlovic, Mladen; Schaller, André; Pfammatter, Jean-Pierre; Carrel, Thierry; Berdat, Pascal; Gallati, Sabina (2005). Age-dependent suppression of SERCA2a mRNA in pediatric atrial myocardium. Biochemical and biophysical research communications, 326(2), pp. 344-8. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2004.11.040

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Differential expression of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) and phospholamban (PLB) has been shown in heart failure and atrial arrhythmias. We investigated the influence of volume overload and age on their expression in pediatric atrial myocardium. Right atrial specimens from 18 children with volume overloaded right atrium (VO) and 12 patients without overload were studied. Each group was further divided into patients less than and older than 12 months of age. Only in the younger patients SERCA2a was significantly reduced in the VO group. In younger patients PLB mRNA level tended to be lower in VO. The PLB:SERCA protein ratio was significantly reduced in the VO group. Age itself did not influence the SERCA2a and PLB expression, if the hemodynamic overload was not taken into account. This study is the first to show a combined influence of volume overload and age on atrial SERCA2a expression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Schaller, André

ISSN:

0006-291X

Publisher:

Academic Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1016/j.bbrc.2004.11.040

PubMed ID:

15582584

Web of Science ID:

000225997300013

URI:

https://boris.unibe.ch/id/eprint/32314 (FactScience: 197378)

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