Association between longitudinal changes in depressive symptoms and plasma fibrinogen levels in school teachers

Von Känel, Roland; Bellingrath, Silja; Kudielka, Brigitte M (2009). Association between longitudinal changes in depressive symptoms and plasma fibrinogen levels in school teachers. Psychophysiology, 46(3), pp. 473-80. Malden, Mass.: Wiley-Blackwell 10.1111/j.1469-8986.2009.00788.x

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Depression and anxiety previously predicted coronary artery disease (CAD) risk. Inflammation contributes to CAD and shows an association with depression. We followed 57 teachers (mean 49+/-8 years) over 21 months and investigated whether changes in depressive and anxiety symptoms relate to those in the CAD risk and inflammation marker fibrinogen and vice versa. Increase in depressive symptoms and in fibrinogen levels were significantly correlated. While controlling for baseline depression rendered the association between changes in depression and fibrinogen nonsignificant, taking into account baseline fibrinogen levels maintained the predictive value of fibrinogen change for depression change. Anxiety and fibrinogen changes were not significantly correlated. This dynamic relationship between depression and the inflammatory biomarker fibrinogen might advance our knowledge about psychobiological mechanisms underlying both CAD and sickness behavior.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland

ISSN:

0048-5772

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.1111/j.1469-8986.2009.00788.x

PubMed ID:

19298625

Web of Science ID:

000265008200004

URI:

https://boris.unibe.ch/id/eprint/32409 (FactScience: 197570)

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