Rauch, Andri; Gaudieri, Silvana; Thio, Chloe; Bochud, Pierre-Yves (2009). Host genetic determinants of spontaneous hepatitis C clearance. Pharmacogenomics, 10(11), pp. 1819-37. London: Future Medicine 10.2217/PGS.09.121
Full text not available from this repository. (Request a copy)Acute infection with the hepatitis C virus (HCV) induces a wide range of innate and adaptive immune responses. A total of 20-50% of acutely HCV-infected individuals permanently control the virus, referred to as 'spontaneous hepatitis C clearance', while the infection progresses to chronic hepatitis C in the majority of cases. Numerous studies have examined host genetic determinants of hepatitis C infection outcome and revealed the influence of genetic polymorphisms of human leukocyte antigens, killer immunoglobulin-like receptors, chemokines, interleukins and interferon-stimulated genes on spontaneous hepatitis C clearance. However, most genetic associations were not confirmed in independent cohorts, revealed opposing results in diverse populations or were limited by varying definitions of hepatitis C outcomes or small sample size. Coordinated efforts are needed in the search for key genetic determinants of spontaneous hepatitis C clearance that include well-conducted candidate genetic and genome-wide association studies, direct sequencing and follow-up functional studies.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Rauch, Andri |
ISSN: |
1462-2416 |
Publisher: |
Future Medicine |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:14 |
Last Modified: |
05 Dec 2022 14:22 |
Publisher DOI: |
10.2217/PGS.09.121 |
PubMed ID: |
19891557 |
Web of Science ID: |
000272024300016 |
URI: |
https://boris.unibe.ch/id/eprint/32462 (FactScience: 197670) |
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