Staphylococcus aureus: new evidence for intracellular persistence

Garzoni, Christian; Kelley, William L (2009). Staphylococcus aureus: new evidence for intracellular persistence. Trends in microbiology, 17(2), pp. 59-65. Cambridge: Elsevier Current Trends 10.1016/j.tim.2008.11.005

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Many reports have documented that Staphylococcus aureus can invade host cells and persist intracellularly for various periods of time in cell culture models. However, it is not clear whether intracellular persistence of S. aureus also occurs in the course of infections in whole organisms. This is a subject of intense debate and is difficult to assess experimentally. Intracellular persistence would provide S. aureus with an ideal strategy to escape from professional phagocytes and extracellular antibiotics and would promote recrudescent infection. Here, we present a brief overview of the mounting evidence that S. aureus has the potential to internalize and survive within host cells.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Garzoni, Christian

ISSN:

0966-842X

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:14

Last Modified:

17 Mar 2015 22:34

Publisher DOI:

10.1016/j.tim.2008.11.005

PubMed ID:

19208480

Web of Science ID:

000264279200003

URI:

https://boris.unibe.ch/id/eprint/32469 (FactScience: 197678)

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