Egermann, U; Stanga, Z; Ramin, A; Acosta, F; Stucki, A; Gerber, P; Cottagnoud, M; Cottagnoud, Ph (2009). Combination of daptomycin plus ceftriaxone is more active than vancomycin plus ceftriaxone in experimental meningitis after addition of dexamethasone. Antimicrobial agents and chemotherapy, 53(7), pp. 3030-3. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00952-08
Full text not available from this repository. (Request a copy)We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for pneumococcal meningitis. The previous addition of dexamethasone affected the antibacterial activity of daptomycin only marginally, either as monotherapy or combined with ceftriaxone, although the penetration of daptomycin into inflamed meninges was significantly reduced from 6 to 2%. Daptomycin with ceftriaxone might be a potential candidate for the empirical therapy of bacterial meningitis, although the activity of this regimen against Listeria monocytogenes remains to be demonstrated.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Egermann, Ulrich, Stanga, Zeno, Stucki, Armin Niklaus, Cottagnoud, Philippe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0066-4804 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:14 |
Last Modified: |
02 Mar 2023 23:23 |
Publisher DOI: |
10.1128/AAC.00952-08 |
PubMed ID: |
19364870 |
Web of Science ID: |
000267354000047 |
URI: |
https://boris.unibe.ch/id/eprint/32696 (FactScience: 197983) |
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