Gumy, Christel; Thurnbichler, Carmen; Aubry, Evelyne M; Balazs, Zoltan; Pfisterer, Petra; Baumgartner, Lisa; Stuppner, Hermann; Odermatt, Alex; Rollinger, Judith M (2009). Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines. Fitoterapia, 80(3), pp. 200-5. Amsterdam: Elsevier Science 10.1016/j.fitote.2009.01.009
Full text not available from this repository.Elevated glucocorticoids are a key risk factor for metabolic diseases, and the glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) represents a promising therapeutic target. We measured the potential of six traditional antidiabetic medicinal plants extracts to inhibit 11beta-HSD1 activity and glucocorticoid receptor (GR) activation in transfected HEK-293 cells. Leave extracts of Eriobotrya japonica preferentially inhibited 11beta-HSD1 over 11beta-HSD2. Extracts of roasted but not native coffee beans preferentially inhibited 11beta-HSD1 over 11beta-HSD2, emphasizing the importance of sample preparation. Thus, natural compounds inhibiting 11beta-HSD1 may contribute to the antidiabetic effect of the investigated plant extracts.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Gumy, Christel |
ISSN: |
0367-326X |
Publisher: |
Elsevier Science |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:14 |
Last Modified: |
05 Dec 2022 14:22 |
Publisher DOI: |
10.1016/j.fitote.2009.01.009 |
PubMed ID: |
19535018 |
Web of Science ID: |
000265572000011 |
URI: |
https://boris.unibe.ch/id/eprint/32704 (FactScience: 198009) |
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