Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines

Gumy, Christel; Thurnbichler, Carmen; Aubry, Evelyne M; Balazs, Zoltan; Pfisterer, Petra; Baumgartner, Lisa; Stuppner, Hermann; Odermatt, Alex; Rollinger, Judith M (2009). Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines. Fitoterapia, 80(3), pp. 200-5. Amsterdam: Elsevier Science 10.1016/j.fitote.2009.01.009

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Elevated glucocorticoids are a key risk factor for metabolic diseases, and the glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) represents a promising therapeutic target. We measured the potential of six traditional antidiabetic medicinal plants extracts to inhibit 11beta-HSD1 activity and glucocorticoid receptor (GR) activation in transfected HEK-293 cells. Leave extracts of Eriobotrya japonica preferentially inhibited 11beta-HSD1 over 11beta-HSD2. Extracts of roasted but not native coffee beans preferentially inhibited 11beta-HSD1 over 11beta-HSD2, emphasizing the importance of sample preparation. Thus, natural compounds inhibiting 11beta-HSD1 may contribute to the antidiabetic effect of the investigated plant extracts.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Gumy, Christel

ISSN:

0367-326X

Publisher:

Elsevier Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:14

Last Modified:

04 May 2014 23:24

Publisher DOI:

10.1016/j.fitote.2009.01.009

PubMed ID:

19535018

Web of Science ID:

000265572000011

URI:

https://boris.unibe.ch/id/eprint/32704 (FactScience: 198009)

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