Threshold-dependent effects on peripheral nerve in vivo excitability properties in the rat

Mori, Atsuko; Nodera, Hiroyuki; Shibuta, Yoshiko; Okita, Takahiro; Bostock, Hugh; Kaji, Ryuji (2010). Threshold-dependent effects on peripheral nerve in vivo excitability properties in the rat. Neuroscience letters, 468(3), pp. 248-53. Amsterdam: Elsevier 10.1016/j.neulet.2009.11.006

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Various factors, including maturity, have been shown to influence peripheral nerve excitability measures, but little is known about differences in these properties between axons with different stimulation thresholds. Multiple nerve excitability tests were performed on the caudal motor axons of immature and mature female rats, recording from tail muscles at three target compound muscle action potential (CMAP) levels: 10%, 40% ("standard" level), and 60% of the maximum CMAP amplitude. Compared to lower target levels, axons at high target levels have the following characteristics: lower strength-duration time constant, less threshold reduction during depolarizing currents and greater threshold increase to hyperpolarizing currents, most notably to long hyperpolarizing currents in mature rats. Threshold-dependent effects on peripheral nerve excitability properties depend on the maturation stage, especially inward rectification (Ih), which becomes inversely related to threshold level. Performing nerve excitability tests at different target levels is useful in understanding the variation in membrane properties between different axons within a nerve. Because of the threshold effects on nerve excitability and the possibility of increased variability between axons and altered electric recruitment order in disease conditions, excitability parameters measured only at the "standard" target level should be interpreted with caution, especially the responses to hyperpolarizing currents.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bostock, Hugh

ISSN:

0304-3940

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:14

Last Modified:

17 Mar 2015 19:17

Publisher DOI:

10.1016/j.neulet.2009.11.006

PubMed ID:

19900504

Web of Science ID:

000273879100018

URI:

https://boris.unibe.ch/id/eprint/3341 (FactScience: 207001)

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