Diurnal variability of C-reactive protein in obstructive sleep apnea

Mills, Paul J; Natarajan, Loki; von Känel, Roland; Ancoli-Israel, Sonia; Dimsdale, Joel E (2009). Diurnal variability of C-reactive protein in obstructive sleep apnea. Sleep & breathing, 13(4), pp. 415-20. Berlin: Springer 10.1007/s11325-009-0268-0

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OBJECTIVE: The objective of this study is to examine the diurnal variability of C-reactive protein (CRP) in obstructive sleep apnea (OSA). METHODS AND MEASUREMENTS: Participants included 44 women and men with untreated OSA (mean apnea/hypopnea index = 37.5, SD +/- 28) and 23 healthy adults with no OSA. Sleep was monitored with polysomnography in the University of California San Diego General Clinical Research Center. Over a 24-h period, blood was collected every 2 h, and CRP levels were determined. RESULTS: Adjusting for age, gender, and body mass index, a significant group by time interaction showed that patients with OSA had higher CRP levels during the daytime (8:00 a.m.-8:00 p.m.) versus the nighttime (10:00 p.m. until 6:00 p.m.; p < 0.001). Non-apneics showed no significant change in CRP levels during the 24 h. CONCLUSIONS: The findings indicate that sleep apnea patients have disproportionately elevated CRP levels in the day versus the nighttime, possibly as a result of carryover effects of nighttime arousal into the daytime.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland








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Date Deposited:

04 Oct 2013 15:15

Last Modified:

04 May 2014 23:24

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https://boris.unibe.ch/id/eprint/33456 (FactScience: 199002)

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