Acute coronary syndromes in young patients: Presentation, treatment and outcome

Schoenenberger, Andreas W; Radovanovic, Dragana; Stauffer, Jean-Christophe; Windecker, Stephan; Urban, Philip; Niedermaier, Gregor; Keller, Pierre-Frederic; Gutzwiller, Felix; Erne, Paul (2011). Acute coronary syndromes in young patients: Presentation, treatment and outcome. International journal of cardiology, 148(3), pp. 300-304. Amsterdam: Elsevier 10.1016/j.ijcard.2009.11.009

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Background: Acute coronary syndromes (ACS) in very young patients have been poorly described. We therefore evaluate ACS in patients aged 35 years and younger. Methods: In this prospective cohort study, 76 hospitals treating ACS in Switzerland enrolled 28,778 patients with ACS between January 1, 1997, and October 1, 2008. ACS definition included ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina (UA). Results: 195 patients (0.7%) were 35 years old or younger. Compared to patients N35 years, these patients were more likely to present with chest pain (91.6% vs. 83.7%; P=0.003) and less likely to have heart failure (Killip class II to IV in 5.2% vs. 23.0%; Pb0.001). STEMI was more prevalent in younger than in older patients (73.1% vs. 58.3%; Pb0.001). Smoking, family history of CAD, and/or dyslipidemia were important cardiovascular risk factors in young patients (prevalence 77.2%, 55.0%, and 44.0%). The prevalence of overweight among young patients with ACS was high (57.8%). Cocaine abuse was associated with ACS in some young patients. Compared to older patients, young patients were more likely to receive early percutaneous coronary interventions and had better outcome with fewer major adverse cardiac events. Conclusions: Young patients with ACS differed from older patients in that the younger often presented with STEMI, received early aggressive treatment, and had favourable outcomes. Primary prevention of smoking, dyslipidemia and overweight should be more aggressively promoted in adolescence.

Item Type:

Journal Article (Original Article)

Division/Institute:

02 Faculty of Law > Management im Gesundheitswesen (MIG)
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Schoenenberger, Andreas; Windecker, Stephan; Keller, Pierre-Frederic and Gutzwiller, Felix

Subjects:

300 Social sciences, sociology & anthropology > 360 Social problems & social services
600 Technology > 610 Medicine & health

ISSN:

0167-5273

ISBN:

19942306

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

30 Jun 2015 16:54

Publisher DOI:

10.1016/j.ijcard.2009.11.009

PubMed ID:

19942306

Web of Science ID:

000289716400019

BORIS DOI:

10.7892/boris.36

URI:

https://boris.unibe.ch/id/eprint/36 (FactScience: 191631)

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