Hyponatremia associated coma due to pituitary apoplexy in early pregnancy: a case report

Krull, Ina; Christ, Emanuel; Kamm, Christian Philipp; Ganter, Christoph; Sahli, Rahel (2010). Hyponatremia associated coma due to pituitary apoplexy in early pregnancy: a case report. Gynecological endocrinology, 26(3), pp. 197-200. London: Informa Healthcare 10.3109/09513590903184118

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Pituitary apoplexy in pregnancy is rare. Its clinical features may range from unspecific complaints to panhypopituitarism resulting even in coma and death. Therefore, alertness to signs and symptoms of acute loss of pituitary function in pregnancy is mandatory. We report a woman in her 7th week of her first gestation presenting with sudden coma due to severe hyponatremia. Secondary adrenal insufficiency could be identified as the underlying cause. Panhypopituitarism including central diabetes insipidus and spontaneous abortion developed during the follow-up. Magnetic resonance imaging showed pituitary apoplexy without a pre-existing pituitary mass. The clinical course was notable for severe complications, including neurological deficits through cerebral ischemia, but eventual recovery could be achieved. We discuss the diagnostic difficulties in the evaluation of pituitary disease in pregnancy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Krull, Ina; Christ, Emanuel; Kamm, Christian Philipp and Sahli, Rahel Gerda

ISSN:

0951-3590

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

06 Dec 2013 13:19

Publisher DOI:

10.3109/09513590903184118

PubMed ID:

19916872

Web of Science ID:

000274856700010

URI:

https://boris.unibe.ch/id/eprint/363 (FactScience: 197859)

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