Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapy

Gast, Heidemarie; Schindler, Kaspar; Z'graggen, Werner J; Hess, Christian W (2010). Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapy. Epilepsy & behavior, 17(4), pp. 555-7. San Diego, Calif.: Elsevier 10.1016/j.yebeh.2010.01.017

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We describe a 61-year-old patient with clinical evidence of limbic encephalitis who improved with anticonvulsant treatment only, that is, without the use of immunosuppressive agents. Three years following occurrence of anosmia, increasing memory deficits, and emotional disturbances, he presented with new-onset temporal lobe epilepsy, with antibodies binding to neuronal voltage-gated potassium channels and bitemporal hypometabolism on FDG-PET scan; the MRI scan was normal. This is most likely a case of spontaneous remission, illustrating that immunosuppressive therapy might be suspended in milder courses of limbic encephalitis. It remains open whether treatment with anticonvulsant drugs played an additional beneficiary role through the direct suppression of seizures or, additionally, through indirect immunomodulatory side effects.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
UniBE Contributor:	Gast, Heidemarie, Schindler, Kaspar Anton, Z'Graggen, Werner Josef, Hess, Christian Walter
ISSN:	1525-5050
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:08
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1016/j.yebeh.2010.01.017
PubMed ID:	20163992
Web of Science ID:	000277446000025
URI:	https://boris.unibe.ch/id/eprint/364 (FactScience: 197862)