Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form

Corazza, Nadia; Brunner, Thomas; Buri, Caroline; Rihs, Silvia; Imboden, Martin A; Seibold, Inge; Mueller, Christoph (2004). Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form. Gastroenterology, 127(3), pp. 816-25. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2004.06.036

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Tumor necrosis factor (TNF) is cleaved proteolytically from a 26-kilodalton transmembrane precursor protein into secreted 17-kilodalton monomers. Transmembrane (tm) and secreted trimeric TNF are biologically active and may mediate distinct activities. We assessed the consequences of a complete inhibition of TNF processing on the course of colitis in recombination activating gene (RAG)2 -/- mice on transfer of CD4 CD45RB hi T cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Buri, Caroline

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:23

Last Modified:

17 Mar 2015 22:49

Publisher DOI:

10.1053/j.gastro.2004.06.036

PubMed ID:

15362037

Web of Science ID:

000223834500018

URI:

https://boris.unibe.ch/id/eprint/37213 (FactScience: 207220)

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