Volumetry and diffusion tensor imaging of hippocampal subregions in schizophrenia

Kalus, Peter; Buri, Caroline; Slotboom, Johannes; Gralla, Jan; Remonda, Luca; Dierks, Thomas; Strik, Werner K; Schroth, Gerhard; Kiefer, Claus (2004). Volumetry and diffusion tensor imaging of hippocampal subregions in schizophrenia. NeuroReport, 15(5), pp. 867-71. London: Lippincott Williams & Wilkins 10.1097/00001756-200404090-00027

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Previous MRI-volumetric studies in schizophrenic psychoses have demonstrated more or less pronounced volume reductions of the hippocampus in patients. Correspondingly, neuropathological examinations on the brains of schizophrenics showed diverse structural changes of the hippocampus. Employing a high-resolution 3D-MPRAGE sequence, we found volume reductions in most hippocampal subregions of schizophrenic patients, which, however, did not reach significant levels. An analysis of co-registered diffusion tensor imaging (DTI) data revealed significant alterations of the inter-voxel coherences in single hippocampal subdivisions of these patients, supporting the assumption of characteristic microstructural tissue changes relevant for the pathogenesis of schizophrenic psychoses. Our results argue for the usage of additional MRI modalities like DTI in order to detect subtle regional alterations of hippocampal structure in schizophrenics.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued]
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Buri, Caroline; Dierks, Thomas and Strik, Werner

ISSN:

0959-4965

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:23

Last Modified:

17 Mar 2015 22:49

Publisher DOI:

10.1097/00001756-200404090-00027

PubMed ID:

15073533

Web of Science ID:

000225140200027

URI:

https://boris.unibe.ch/id/eprint/37214 (FactScience: 207221)

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