Growth hormone replacement in adults with growth hormone deficiency: assessment of current knowledge

Carroll, P V; Christ, E R; Sönksen, P H (2000). Growth hormone replacement in adults with growth hormone deficiency: assessment of current knowledge. Trends in endocrinology and metabolism, 11(6), pp. 231-8. Kidlington, UK: Elsevier Current Trends 10.1016/S1043-2760(00)00268-X

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The recent availability of recombinant human growth hormone (GH) has led to intense investigation of the consequences of adult GH deficiency (GHD) and the effects of GH replacement. These studies have led to the identification of a characteristic syndrome of GHD consisting of decreased mood and well-being, with alterations in body composition and substrate metabolism. In both placebo-controlled and open studies, GH replacement therapy has consistently been shown to reverse or correct these features. Whether long-term GH replacement will result in a reduction of osteoporotic fractures, cardiovascular morbidity and mortality is not yet known. To date, no permanent serious adverse effects have been associated with GH replacement in GHD, and although currently expensive, it is anticipated that GH replacement will become routine in the treatment of the severely hypopituitary adult.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Christ, Emanuel

ISSN:

1043-2760

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:23

Last Modified:

17 Mar 2015 22:49

Publisher DOI:

10.1016/S1043-2760(00)00268-X

PubMed ID:

10878754

Web of Science ID:

000088670500006

URI:

https://boris.unibe.ch/id/eprint/37229 (FactScience: 207241)

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