Occurrence of Leishmania sp. in cutaneous lesions of horses in Central Europe

Müller, Norbert; Welle, Monika Maria; Lobsiger, Lisbeth; Stoffel, Michael Hubert; Kühni, Kathrin; Hilbe, Monika; Gottstein, Bruno; Frey, Caroline; Geyer, Claudia; von Bomhard, Wolf (2009). Occurrence of Leishmania sp. in cutaneous lesions of horses in Central Europe. Veterinary parasitology, 166(3-4), pp. 346-351. Amsterdam: Elsevier 10.1016/j.vetpar.2009.09.001

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The present report describes a novel etiological agent of cutaneous leishmaniasis in horses that, at least for some cases, sporadically appeared as autochthonous infections in geographically distant regions of Germany and Switzerland. The infection was initially diagnosed upon clinical and immunohistological findings. Subsequent comparative sequence analysis of diagnostic PCR products from the internal transcribed spacer 1 (ITS1) of ssrRNA classified the respective isolates as neither Old World nor New World Leishmania species. However, four isolates subjected to molecular analyses all exhibited a close phylogenetic relationship to Leishmania sp. siamensis, an organism recently identified in a visceral leishmaniasis patient from Thailand. Future investigations will demonstrate if this form of leishmaniasis represents an emerging, and perhaps zoonotic, disease of European, or even global, importance.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Müller, Norbert; Welle, Monika Maria; Stoffel, Michael Hubert; Kühni, Kathrin; Gottstein, Bruno and Frey, Caroline

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0304-4017

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:24

Last Modified:

28 Jan 2016 15:15

Publisher DOI:

10.1016/j.vetpar.2009.09.001

PubMed ID:

19800739

BORIS DOI:

10.7892/boris.37775

URI:

https://boris.unibe.ch/id/eprint/37775 (FactScience: 210661)

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