Stahl, C.; Unger, Lucia; Mazuet, C.; Popoff, M.; Straub, R.; Frey, J. (2009). Immune response of horses to vaccination with the recombinant Hc domain of botulinum neurotoxin types C and D. Vaccine, 27(41), pp. 5661-6. Amsterdam: Elsevier 10.1016/j.vaccine.2009.07.021
Full text not available from this repository.Botulinum neurotoxins, predominantly serotypes C and D, cause equine botulism through forage poisoning. The C-terminal part of the heavy chain of botulinum neurotoxin types C and D (HcBoNT/C and D) was expressed in Escherichia coli and evaluated as a recombinant mono- and bivalent vaccine in twelve horses in comparison to a commercially available toxoid vaccine. A three-dose subcutaneous immunization of adult horses elicited robust serum antibody response in an ELISA using the immunogen as a capture antigen. Immune sera showed dose-dependent high potency in neutralizing specifically the active BoNT/C and D in the mouse protection assay. The aluminium hydroxide based mono- and bivalent recombinant HcBoNT/C and D vaccines were characterized by good compatibility and the ability to elicit protective antibody titers similar or superior to the commercially available toxoid vaccine.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > ISME Equine Clinic Bern > ISME Equine Clinic, Internal medicine 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology |
UniBE Contributor: |
Precht, Maria Christina, Unger, Lucia, Straub, Reto, Frey, Joachim |
ISSN: |
0264-410X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:24 |
Last Modified: |
02 Mar 2023 23:23 |
Publisher DOI: |
10.1016/j.vaccine.2009.07.021 |
Web of Science ID: |
000270070400017 |
URI: |
https://boris.unibe.ch/id/eprint/38229 (FactScience: 220747) |
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