Selective iNOS-inhibition does not influence apoptosis in ruptured canine cranial cruciate ligaments

Hofer, D.; Forterre, Simone; Schweighauser, Ariane; Krayer, M.; Doherr, Marcus; Schawalder, Peter; Zurbriggen, Andreas; Spreng, David (2009). Selective iNOS-inhibition does not influence apoptosis in ruptured canine cranial cruciate ligaments. Veterinary and comparative orthopaedics and traumatology, 22(3), pp. 198-203. Stuttgart: Schattauer 10.3415/VCOT-08-09-0078

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Abnormal patterns of cell death, including increased apoptosis, can influence homeostasis of ligaments and could be involved in the pathogenesis of cranial cruciate ligament (CCL) rupture. Increased nitric oxide (NO) production has been implicated as a stimulus to increased apoptosis in articular cartilage. This study investigated apoptotic cell death in ruptured canine CCL (CCL group, n = 15), in ruptured CCL of dogs treated with oral L-N6-(1-iminoethyl)-lysine (L-NIL), a selective NO-synthetase(NOS)-inhibitor, (L-NIL group, n = 15) and compared the results with normal canine CCL (control group, n = 10). Orally administered L-NIL at a dosage of 25mg/m2 of body surface area was effective in inhibiting NO production in the articular cartilage of dogs in the L-NIL group, but it did not significantly influence the increased quantity of apoptotic cells found in ruptured CCL specimens. The results of this study suggest that apoptosis of ligamentocytes in the canine CCL is not primarily influenced by increased NO production within the stifle joint.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Internal Medicine
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research (discontinued)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Forterre, Simone; Schweighauser, Ariane; Doherr, Marcus; Schawalder, Peter; Zurbriggen, Andreas and Spreng, David

Subjects:

600 Technology > 630 Agriculture

ISSN:

0932-0814

Publisher:

Schattauer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

16 Feb 2015 15:54

Publisher DOI:

10.3415/VCOT-08-09-0078

Web of Science ID:

000267272700005

URI:

https://boris.unibe.ch/id/eprint/38245 (FactScience: 220763)

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