Polyganglioradiculoneuritis in a young cat: clinical and histopathological findings

Henke, D.; Vandevelde, M.; Oevermann, A. (2009). Polyganglioradiculoneuritis in a young cat: clinical and histopathological findings. Journal of small animal practice, 50(5), pp. 246-50. Oxford: Pergamon Press 10.1111/j.1748-5827.2009.00703.x

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An 18-month-old European shorthair cat was presented with a two week history of progressive decrease in consciousness, ambulatory tetraparesis, moderate ataxia and generalised decreased-to-absent postural reactions. Bilateral facial and nasal hypalgesia, absent menace response and anisocoria were found, and segmental spinal reflexes were normal. Neurological signs progressed to nonambulatory tetraparesis, tremor and spinal hyperalgesia. Histopathological examination revealed a mild-to-moderate lymphoplasmacytic and histiocytic infiltration, predominantly in the dorsal spinal roots, cranial nerves and ganglia in association with marked demyelination and proliferation of Schwann cells. Neurons and axons were preserved. Lesions were multi-focal and varied in severity. A predominantly sensory polyganglioradiculoneuritis was diagnosed. This lesion has not been reported previously in cats. Rabies, herpesviruses, feline infectious peritonitis, feline immunodeficiency virus, Toxoplasma gondii and feline leukaemia virus were excluded as possible aetiologies. Infections by other viruses or an autoimmune disease are discussed.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Henke, Diana; Vandevelde, Marc and Oevermann, Anna

ISSN:

0022-4510

Publisher:

Pergamon Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1111/j.1748-5827.2009.00703.x

Web of Science ID:

000265615000007

URI:

https://boris.unibe.ch/id/eprint/38261 (FactScience: 220781)

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