Genome sequence, comparative analysis, and population genetics of the domestic horse

Wade, C.M.; Giulotto, E.; Sigurdsson, S.; Zoli, M.; Gnerre, S.; Imsland, F.; Lear, T.L.; Adelson, D.L.; Bailey, E.; Bellone, R.R.; Blocker, H.; Distl, O.; Edgar, R.C.; Garber, M.; Leeb, Tosso; Mauceli, E.; MacLeod, J.N.; Penedo, M.C.; Raison, J.M.; Sharpe, T.; ... (2009). Genome sequence, comparative analysis, and population genetics of the domestic horse. Science, 326(5954), pp. 865-7. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1178158

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We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Leeb, Tosso

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

16 Feb 2015 08:56

Publisher DOI:

10.1126/science.1178158

Web of Science ID:

000271468000047

URI:

https://boris.unibe.ch/id/eprint/38292 (FactScience: 220947)

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