Primary splenic peripheral nerve sheath tumour in a dog

Bergmann, W.; Burgener, I.A.; Roccabianca, P.; Rytz, U.; Welle, M. (2009). Primary splenic peripheral nerve sheath tumour in a dog. Journal of comparative pathology, 141(2-3), pp. 195-8. London: Elsevier 10.1016/j.jcpa.2009.03.009

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An 8-year-old crossbred dog was presented with a one-month history of progressive weakness, respiratory impairment and abdominal distension. Surgical exploration revealed the presence of a splenic mass that infiltrated the mesentery and was adherent to the stomach and pancreas. The mass was composed of highly cellular areas of spindle-shaped cells arranged in interlacing bundles, streams, whorls and storiform patterns (Antoni A pattern) and less cellular areas with more loosely arranged spindle to oval cells (Antoni B pattern). The majority of neoplastic cells expressed vimentin, S-100 and glial fibrillary acidic protein (GFAP), but did not express desmin, alpha-smooth muscle actin or factor VIII. These morphological and immunohistochemical findings characterized the lesion as a malignant peripheral nerve sheath tumour (PNST). Primary splenic PNST has not been documented previously in the dog.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
UniBE Contributor:	Burgener, Iwan, Rytz, Ulrich, Welle, Monika Maria
ISSN:	0021-9975
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:25
Last Modified:	05 Dec 2022 14:26
Publisher DOI:	10.1016/j.jcpa.2009.03.009
Web of Science ID:	000268348600015
URI:	https://boris.unibe.ch/id/eprint/38313 (FactScience: 220996)