Primary splenic peripheral nerve sheath tumour in a dog

Bergmann, W.; Burgener, I.A.; Roccabianca, P.; Rytz, U.; Welle, M. (2009). Primary splenic peripheral nerve sheath tumour in a dog. Journal of comparative pathology, 141(2-3), pp. 195-8. London: Elsevier 10.1016/j.jcpa.2009.03.009

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An 8-year-old crossbred dog was presented with a one-month history of progressive weakness, respiratory impairment and abdominal distension. Surgical exploration revealed the presence of a splenic mass that infiltrated the mesentery and was adherent to the stomach and pancreas. The mass was composed of highly cellular areas of spindle-shaped cells arranged in interlacing bundles, streams, whorls and storiform patterns (Antoni A pattern) and less cellular areas with more loosely arranged spindle to oval cells (Antoni B pattern). The majority of neoplastic cells expressed vimentin, S-100 and glial fibrillary acidic protein (GFAP), but did not express desmin, alpha-smooth muscle actin or factor VIII. These morphological and immunohistochemical findings characterized the lesion as a malignant peripheral nerve sheath tumour (PNST). Primary splenic PNST has not been documented previously in the dog.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology

UniBE Contributor:

Burgener, Iwan; Rytz, Ulrich and Welle, Monika Maria

ISSN:

0021-9975

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1016/j.jcpa.2009.03.009

Web of Science ID:

000268348600015

URI:

https://boris.unibe.ch/id/eprint/38313 (FactScience: 220996)

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